Human Myosin Complement

Summary tables

There appear to be 39 genes for myosin in the human genome, although others may remain to be identified. The following tables show the distribution of the myosins among different classes and human chromosomes.

Myosins by Class Myosins by Chromosome
Class Count
I 8
II 14
III 2
IV 0
V 3
VI 1
VII 2
VIII 0
IX 2
X 1
XI 0
XII 0
XIII 0
XIV 0
XV 2
XVI 1
XVII 0
XVIII 2
? 1
Total 39
Chromosome Count
1 0
2 3
3 1
4 0
5 1
6 1
7 1
8 0
9 0
10 1
11 1
12 2
13 1
14 2
15 4
16 1
17 13
18 1
19 3
20 1
21 0
22 2
X 0
Y 0
Total 39

Myosin Listing

The following table aims to provide a summary of all the myosin genes identified in the human genome. Due to the fragmentary nature of the genome, and the incompleteness of its annotation, this should not be taken as a complete list.

Chromosome Arm Band Class Designation Ensembl gene ID OMIM Description or comment
12
 q 14.1 I MYO1A ENSG00000123339 601478 Brush border myosin I
2 q 32.3 MYO1B ENSG00000128641    
17 p 13.3 MYO1C ENSG00000113203    
17 q 11.2 MYO1D ENSG00000077002    
15 q 22.1 MYO1E ENSG00000137775 601479 Not in database (assembly errors)
19 p 13.2 MYO1F ENSG00000071737 601480  
7 p 12.3 MYO1G? ENSG00000136286   From Genome
12 q 24.21 MYO1H? ENSG00000139446   From Genome
17 p 12 II MYH1 ENSG00000109061 160730 Skeletal II X/D
17 p 12 MYH2 ENSG00000125414 160740 Skeletal II A
17 p 12 MYH3 ENSG00000109063 160720 Skeletal Embryonic
17 p 13.1 MYH4 ENSG00000141048 160742 Skeletal II B
14 q 11.2 MYH6 ENSG00000092055 160710 Cardiac alpha
14 q 11.2 MYH7 ENSG00000092054 160760 Cardiac beta (FHC)
17 p 13.1 MYH8 ENSG00000133020 160741 Skeletal perinatal
22 q 12.3 MYH9 ENSG00000100345 160775 Non-muscle A
17 p 13.1 MYH10 ENSG00000133026 160776 Non-muscle B
16 p 13.12 MYH11 ENSG00000133392 160745 Smooth Muscle
17 p 13.1 MYH13 ENSG00000006788 603487 Extraocular
20 q 11.22 MYH14? ENSG00000078814   From Genome
3 q 13.2 MYH15? ENSG00000144818   From Genome (fragmentary)
19 q 13.33 MYH16? ENSG00000105357   From Genome (fragmentary)
10 p 12.1 III MYO3A ENSG00000095777   NinaC like
2 q 31.1 MYO3B? ENSG00000144371   From Genome (fragmentary)
15 q 21.2 V MYO5A ENSG00000047343 160777 Griscelli syndrome
18 q 21.2 MYO5B ENSG00000101691   Fragmentary
15 q 21.2 MYO5C ENSG00000128833    
6 q 14.1 VI MYO6 ENSG00000112698 600970 DFNA22,"Snell's Waltzer"
11 q 14.1 VII MYO7A ENSG00000137474 276903 Usher 1b, DFNB2, DFNA11, "shaker-1"
2 q 21.2 MYO7B ENSG00000144245    
15 q 24.1 IX MYO9A ENSG00000066933 604875  
19 p 13.11 MYO9B ENSG00000099331 602129  
5 p 15.1 X MYO10 ENSG00000145555 601481  
17 p 11.2 XV MYO15A ENSG00000091536   DFNB3,"shaker-2"
17 q 25.1 MYO15B ENSG00000109112   Fragmentary
13 q 33.3 XVI MYO16 ENSG00000041515 602666  
17 q 11.2 XVIII MYO18A ENSG00000109123   PDZ myosins
22 q 12.1 MYO18B? ENSG00000133454  
17 q 21.1 ? MYO? ENSG00000108277   Orphan - class unclear

Note: This table was assembled using export function of Ensembl Version 1.2.0 on 14/11/2001, using the August 2001 dataset. The database was searched for genes containing either the PFAM or InterPro motifs corresponding to the myosin head sequence. The list will therefore not include pseudogenes or genes which were not identified by the GenScan software. Because of the fragmentary nature of the genome, and also because the automated annotation is imperfect, some genes are fragmentary: either exons are missing, or have been allocated to more than one gene. In these cases the main Ensembl gene in each case is listed. In the case of myosin IE, a previous gene entry has been removed from the database. The gene sequence appears to be present instead in fragmentary form on a stretch of DNA which has not been assigned to a chromosome. The gene appears in two main fragments (ENSG00000142347, ENSG00000142351) which are on opposite strands of the genomic sequence AC092298, which perhaps suggests incorrect assembly. The gene identified by Berg et al. as MYO15B was not found in this search. However it was found in a BLAST search using the MYO15A sequence, and a gene representing a fragment of the protein has been added to the table above. (This fragment does not contain any part of the myosin head sequence, but there are clear homologies in the genomic sequence nearby).

Nomeclature

The nomeclature used is that adopted in the following references:

Berg, J.S., Powell, B.C. and Cheney, R.E. (2001). “A Millennial Myosin Census.” Molecular Biology of the Cell 12: 780-794. [Abstract] [HTML] [PDF]

Peter G. Gillespie, Joseph P. Albanesi, Martin Bähler, William M. Bement, Jonathan S. Berg, David R. Burgess, Beth Burnside, Richard E. Cheney, David P. Corey, Evelyne Coudrier, Primal de Lanerolle, John A. Hammer, Tama Hasson, Jeffrey R. Holt, A.J. Hudspeth, Mitsuo Ikebe, John Kendrick-Jones, Edward D. Korn, Rong Li, John A. Mercer, Ronald A. Milligan, Mark S. Mooseker, E. Michael Ostap, Christine Petit, Thomas D. Pollard, James R. Sellers, Thierry Soldati and Margaret A. Titus (2001). "Myosin-I nomenclature," Journal of Cell Biology, 155(5):703-704 [HTML][PDF]

Note that some of the nomenclature used in the genome annotations is incorrect. Clicking on the gene identifier gives access to information on each gene, transcripts, chromosomal location, etc.

Comments and updates

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